John M Kokontis Selected Research

T0901317

4/2011	A novel potent synthetic steroidal liver X receptor agonist lowers plasma cholesterol and triglycerides and reduces atherosclerosis in LDLR(-/-) mice.
9/2007	Modulation of liver X receptor signaling as novel therapy for prostate cancer.
6/2007	The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells.
7/2006	Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist.
11/2004	Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

John M Kokontis Research Topics

Disease

15	Prostatic Neoplasms (Prostate Cancer) 01/2014 - 07/2004
10	Neoplasms (Cancer) 05/2012 - 11/2004
4	Cardiovascular Diseases (Cardiovascular Disease) 11/2011 - 11/2004
2	Fatty Liver 07/2011 - 04/2011
2	Breast Neoplasms (Breast Cancer) 09/2007 - 11/2004
1	Disease Progression 08/2011
1	Hypertriglyceridemia 07/2011
1	Atherosclerosis 04/2011
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2004

Drug/Important Bio-Agent (IBA)

10	AndrogensIBA 01/2014 - 07/2004
6	Androgen Receptors (Androgen Receptor)IBA 01/2014 - 12/2005
6	Liver X ReceptorsIBA 07/2011 - 11/2004
5	T0901317IBA 04/2011 - 11/2004
4	Prostate-Specific Antigen (Semenogelase)IBA 11/2011 - 03/2005
3	Testosterone (Sustanon)FDA Link 11/2011 - 07/2006
3	LipidsIBA 07/2011 - 11/2004
2	CholesterolIBA 04/2011 - 11/2004
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 09/2007 - 11/2004
2	Androgen Antagonists (Antiandrogens)IBA 06/2007 - 12/2005
2	Messenger RNA (mRNA)IBA 06/2007 - 03/2005
2	Proteins (Proteins, Gene)FDA Link 06/2007 - 03/2005
2	Gonadal Steroid Hormones (Sex Hormones)IBA 11/2004 - 11/2004
1	AgarIBA 01/2013
1	caffeic acid phenethyl esterIBA 05/2012
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 05/2012
1	Hormones (Hormone)IBA 11/2011
1	Pharmaceutical PreparationsIBA 07/2011
1	LDL Receptors (LDL Receptor)IBA 07/2011
1	CholatesIBA 07/2011
1	Triglycerides (Triacylglycerol)IBA 04/2011
1	PolyphenolsIBA 03/2009
1	TeaIBA 03/2009
1	campesterolIBA 09/2007
1	Phytosterols (Plant Sterols)IBA 09/2007
1	gamma-sitosterol (beta-sitosterol)IBA 09/2007
1	Small Interfering RNA (siRNA)IBA 06/2007
1	Androgen Receptor AntagonistsIBA 06/2007
1	Oncogene Proteins (Oncogene Protein)IBA 06/2007
1	bicalutamide (Casodex)FDA LinkGeneric 12/2005
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 11/2004
1	PolyaminesIBA 07/2004
1	Mitoguazone (MGBG)IBA 07/2004

Therapy/Procedure

8	Therapeutics 01/2014 - 03/2005
4	Castration 01/2014 - 07/2006
1	Oral Administration 11/2004